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ibacteroides"},{"key":"Atopobium","name":"Atopobium"},{"key":"MGBC119817","name":"MGBC119817"},{"key":"Mesosutterella","name":"Mesosutterella"},{"key":"Clostridium","name":"Clostridium"},{"key":"Alloscardovia","name":"Alloscardovia"},{"key":"Desulfonispora","name":"Desulfonispora"},{"key":"Petroclostridium","name":"Petroclostridium"},{"key":"Onthenecus","name":"Onthenecus"},{"key":"UMGS1649","name":"UMGS1649"},{"key":"Geddesella","name":"Geddesella"},{"key":"C-53","name":"C-53"},{"key":"RUG131","name":"RUG131"},{"key":"Clostridium","name":"Clostridium"},{"key":"Clostridium","name":"Clostridium"},{"key":"Bacillus","name":"Bacillus"},{"key":"RGIG5622","name":"RGIG5622"},{"key":"Schneewindia","name":"Schneewindia"},{"key":"Bacillus","name":"Bacillus"},{"key":"Clostridium","name":"Clostridium"},{"key":"Clostridium","name":"Clostridium"},{"key":"Clostridium","name":"Clostridium"},{"key":"GWF2-43-63","name":"GWF2-43-63"},{"key":"RPQJ01","name":"RPQJ01"},{"key":"Soonwooa","name":"Soonwooa"},{"key":"SDRW01","name":"SDRW01"},{"key":"Bacillus","name":"Bacillus"},{"key":"Atopostipes","name":"Atopostipes"},{"key":"Proteiniborus","name":"Proteiniborus"},{"key":"Bacillus","name":"Bacillus"},{"key":"FJAT-45066","name":"FJAT-45066"},{"key":"Ancylomarina","name":"Ancylomarina"},{"key":"Bacillus","name":"Bacillus"},{"key":"Marinisoma","name":"Marinisoma"},{"key":"Virgibacillus","name":"Virgibacillus"},{"key":"Allobacillus","name":"Allobacillus"},{"key":"Bacillus","name":"Bacillus"},{"key":"Faecenecus","name":"Faecenecus"},{"key":"RGIG3586","name":"RGIG3586"},{"key":"UBA12018","name":"UBA12018"},{"key":"Thermophagus","name":"Thermophagus"},{"key":"Malacoplasma","name":"Malacoplasma"},{"key":"JADKBO01","name":"JADKBO01"},{"key":"Bacillus","name":"Bacillus"},{"key":"Clostridium","name":"Clostridium"},{"key":"Bacillus","name":"Bacillus"},{"key":"Bacillus","name":"Bacillus"},{"key":"Bacillus","name":"Bacillus"},{"key":"Enterococcus","name":"Enterococcus"},{"key":"Bacillus","name":"Bacillus"},{"key":"Leuconostoc","name":"Leuconostoc"},{"key":"Bacillus","name":"Bacillus"},{"key":"CAG-568","name":"CAG-568"},{"key":"Bacillus","name":"Bacillus"},{"key":"Bacillus","name":"Bacillus"},{"key":"Bacillus","name":"Bacillus"},{"key":"Bacillus","name":"Bacillus"},{"key":"Pseudomonas","name":"Pseudomonas"},{"key":"Nereida","name":"Nereida"},{"key":"","name":"Enterococcaceae 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inflammation.","test_pearson_r":0.6942,"intercept":14.349727630615234,"coef":[[0,-0.27034232020378113],[2,-0.18564042448997498],[3,-0.0015160657931119204],[4,-0.6962717175483704],[5,-1.65933096408844],[6,0.0004150346794631332],[7,3.005101203918457],[8,-0.5579303503036499],[9,0.2699827253818512],[10,-0.13620486855506897],[12,-0.0007130166050046682],[14,-0.14683020114898682],[17,-1.0852408409118652],[18,-0.107453852891922],[22,-0.23918913304805756],[23,-1.0648994445800781],[24,-0.1647264063358307],[25,-0.027292687445878983],[26,-0.7080629467964172],[29,-4.249956130981445],[30,-0.034755416214466095],[31,-0.05213809013366699],[32,-0.49003803730010986],[33,-0.19761353731155396],[34,-0.08214130252599716],[35,-0.5029476284980774],[36,-0.015997590497136116],[37,-0.13297174870967865],[38,-2.4202332496643066],[39,-0.9617030024528503],[40,-0.06633338332176208],[41,0.02799810841679573],[42,-0.16268491744995117],[44,-0.20103201270103455],[45,-0.024201789870858192],[46,-0.22233358025550842],[47,-0.41749000549316406],[48,-0.09050893783569336],[50,-0.49405938386917114],[51,-0.03245427459478378],[52,-0.4399994909763336],[53,-0.30981194972991943],[56,-2.067955493927002],[57,-1.134008526802063],[60,0.20556168258190155],[62,-0.6292141675949097],[63,-0.15038885176181793],[64,-0.3046688139438629],[65,-0.06988314539194107],[66,-0.2109280377626419],[67,-0.037227269262075424],[68,-0.6100130081176758],[69,-0.33285343647003174],[70,-0.018403271213173866],[71,-0.6653587818145752],[72,-0.35144883394241333],[73,-1.5504982471466064],[75,-0.042722057551145554],[76,1.8337973356246948],[77,-0.2926115393638611],[79,0.3410334587097168],[80,-0.2049020379781723],[81,-0.19961774349212646],[82,-0.13396508991718292],[83,-0.2449595183134079],[85,-0.07117174565792084],[87,-0.236237034201622],[88,-0.060590848326683044],[89,0.3325376510620117],[90,-0.00487985135987401],[92,0.11021572351455688],[93,-0.11183329671621323],[94,-0.7885578274726868],[95,-0.01401924155652523],[96,-0.0011091030901297927],[97,-0.31663113832473755],[98,-0.38000959157943726],[99,-0.11621399968862534],[100,-0.00011543255823198706],[101,2.53202486038208],[102,-1.6778712272644043],[104,-0.2584536075592041],[105,-0.000785158306825906],[106,-0.20851948857307434],[107,0.4132329523563385],[108,-0.1101723313331604],[109,-0.015938689932227135],[110,-0.9406670928001404],[111,-0.6146480441093445],[112,-0.9845767617225647],[115,-0.2267168015241623],[117,-0.07694742828607559],[118,-0.2786104679107666],[119,-0.23336255550384521],[120,-0.1457827091217041],[121,-0.05042319372296333],[122,-0.04026167467236519],[123,-1.1989684104919434],[124,-0.01389404945075512],[126,-0.18041744828224182],[127,-0.02138930931687355],[128,-0.031325750052928925],[130,-5.725447654724121],[131,-0.2934434413909912],[134,-0.3455072045326233],[135,-0.768771767616272],[136,-0.1423148363828659],[139,-0.24611151218414307],[141,-0.5067399144172668],[142,-0.36963769793510437],[143,0.8387885689735413],[145,-0.002892761491239071],[146,-0.12818115949630737],[147,-0.3083837926387787],[148,-0.19982510805130005],[150,-0.1815013736486435],[152,-1.6276055574417114],[153,-1.7613334655761719],[155,-0.11189662665128708],[157,-0.25263363122940063],[159,-0.34221774339675903],[160,-0.017964445054531097],[161,-0.589341938495636],[162,-0.10549776256084442],[164,-0.6047658920288086],[165,-0.4885256886482239],[166,-0.1859717220067978],[168,-0.4909651577472687],[169,-0.05367141589522362],[170,0.40400439500808716],[171,-0.33978208899497986],[172,-1.6420501470565796],[173,-0.09106073528528214],[176,-0.011869763024151325],[177,-0.18302232027053833],[178,-1.071710467338562],[179,-0.6353461146354675],[180,-2.105203866958618],[181,-0.1979829967021942],[182,-3.0849623680114746],[183,-0.17013594508171082],[184,-0.429980605840683],[186,-0.00107372528873384],[188,-0.0964164063334465],[189,-0.36077994108200073],[190,-5.349758625030518],[191,-0.4894793927669525],[192,-0.1941094696521759],[193,-0.1586717963218689],[194,-0.05500669777393341],[196,-1.3624836206436157],[199,0.10928483307361603],[201,-0.11743238568305969],[203,-1.0920206308364868],[204,-0.5927888751029968],[205,-3.5177900791168213],[208,-0.45325684547424316],[209,-0.18712957203388214],[210,-1.902759075164795],[211,-0.4809432029724121],[212,-0.09016219526529312],[213,-0.4459734261035919],[216,-0.037515655159950256],[217,-0.10563132911920547],[218,-0.0016912557184696198],[219,-0.6032895445823669],[220,-0.5110605359077454],[221,-0.1566803753376007],[222,-0.08370906114578247],[225,-0.45384225249290466],[226,2.2817392349243164],[227,-0.7499771118164062],[228,-0.16093812882900238],[229,0.05375393107533455],[230,-0.6714183688163757],[232,-1.389082908630371],[233,-0.10462840646505356],[234,-0.18338564038276672],[235,-6.487372875213623],[236,-0.3735183775424957],[237,-0.27648094296455383],[238,-0.5418015122413635],[240,0.01597166806459427],[241,-0.0013960457872599363],[242,-0.24579967558383942],[243,-0.6894397139549255],[245,-0.05857163667678833],[246,-0.19756202399730682],[247,-2.5064475536346436],[24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fatty acid","explanation":"The most abundant short-chain fatty acid in the gut, produced by a very wide range of bacteria during fermentation.","why_it_matters":"Much of it is absorbed and used elsewhere in the body as an energy source, and it is a building block other gut bacteria convert into 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fatty acid","explanation":"A short-chain fatty acid produced during fibre fermentation, particularly by Bacteroides species.","why_it_matters":"Largely taken up by the liver, where it participates in glucose metabolism. 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(trimethylamine-N-oxide)","family":"Microbial-host co-metabolite","explanation":"Made in two steps: gut bacteria convert choline and carnitine (from foods like red meat, eggs and fish) into trimethylamine, and the liver then oxidises it into TMAO.","why_it_matters":"One of the most-studied examples of gut bacteria producing a compound that circulates in the blood. Higher circulating TMAO has been associated with cardiovascular risk in multiple cohorts, although the causal role is actively debated and fish consumption raises it 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metabolite","explanation":"Produced when gut bacteria break down tryptophan, an amino acid from dietary protein.","why_it_matters":"Studied for antioxidant activity and for associations with gut barrier function; lower levels have been reported in type 2 diabetes cohorts.","test_pearson_r":0.8385,"intercept":9.803220748901367,"coef":[[7,0.6160203218460083],[60,-0.12345784902572632],[76,3.2508676052093506],[101,2.996535539627075],[130,-2.518292188644409],[180,-0.6352035403251648],[190,0.6647855639457703],[196,-6.31859016418457],[208,-2.2758967876434326],[226,0.7246970534324646],[235,-2.61456036567688],[263,-1.0545589923858643],[279,-8.603338241577148],[283,-0.6080670356750488],[313,-0.2980269491672516],[382,-5.467104911804199],[491,-0.03899087756872177],[557,0.8899516463279724],[581,0.9772325158119202],[596,-2.881171226501465],[601,-10.83537483215332],[613,4.333859920501709],[614,-5.300546169281006],[630,-3.0461082458496094],[636,-0.02608676627278328],[739,-5.931125640869141],[807,-0.6803760528564453],[834,-5.9041290283203125],[845,-7.115342140197754],[855,0.2644900381565094],[869,0.3016017973423004],[879,1.0427809953689575],[916,-0.939277708530426],[933,3.8798577785491943],[1257,-18.835620880126953],[1261,-1.319501280784607],[1265,-1.633133053779602]],"quantiles":[0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0227,0.0618,0.0821,0.1062,0.1456,0.1738,0.1939,0.2252,0.2493,0.2865,0.344,0.386,0.4174,0.4588,0.5113,0.5846,0.6545,0.6972,0.757,0.8093,0.8712,0.9396,1.0003,1.0823,1.1417,1.2058,1.2901,1.3548,1.4211,1.5224,1.5885,1.7143,1.8749,2.2562,2.8899,7.8063,8.2694,8.8948,9.5303,9.9798,10.3927,10.5201,10.6242,10.7099,10.8299,10.8909,10.9939,11.0812,11.1576,11.2346,11.2924,11.361,11.4613,11.545,11.6174,11.6909,11.7448,11.814,11.8793,11.9168,12.0176,12.0944,12.1428,12.2006,12.2748,12.393,12.5273,12.603,12.7037,12.8006,12.9218,13.0436,13.1609,13.3029,13.4635,13.6465,13.8321,13.9545,14.1447,14.3231,14.5532,14.8633,15.1832,15.4605,16.3961]},{"hmdb_id":"HMDB0000626","name":"Deoxycholate","family":"Secondary bile acid","explanation":"Made by gut bacteria chemically modifying the primary bile acid cholate.","why_it_matters":"A clear example of bacteria transforming a host molecule into something with different biological activity. Secondary bile acids have been studied both for protective signalling roles and, at high levels, for associations with colorectal cancer risk.","test_pearson_r":0.7088,"intercept":9.533990859985352,"coef":[[101,3.2298009395599365],[557,3.6913578510284424],[601,-5.778667449951172],[613,0.13392774760723114],[824,0.4624010920524597],[855,0.0730295181274414],[1257,-19.96482276916504],[1261,-2.799160957336426]],"quantiles":[0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0349,0.0843,0.119,0.1538,0.2067,0.2617,0.3373,0.4021,0.4811,0.6721,3.3909,5.1693,6.2636,6.707,6.9709,7.2192,7.647,7.8932,8.0689,8.2466,8.4292,8.5039,8.6783,8.785,8.8743,8.9606,9.0175,9.0906,9.113,9.1713,9.2281,9.2905,9.3531,9.4536,9.5476,9.5816,9.615,9.6516,9.7006,9.7292,9.7838,9.8271,9.8776,9.9329,10.0648,10.1748,10.3083,10.4759,10.5804,10.6446,10.7167,10.8266,10.9352,11.0375,11.2483,13.2504,13.9768,14.7565,15.2568,15.6337,15.9687,16.2563,16.4082,16.6058,16.8531,17.0153,17.1587,17.2507,17.4024,17.4833,17.5525,17.6336,17.751,17.8057,17.8743,17.9514,18.0393,18.0931,18.1838,18.2657,18.323,18.3991,18.4812,18.5669,18.6782,18.7684,18.9637,19.7194]},{"hmdb_id":"HMDB0000619","name":"Cholate","family":"Primary bile acid","explanation":"A bile acid your liver makes from cholesterol and releases into the gut to help digest fat.","why_it_matters":"Most is reabsorbed and recycled. What reaches the colon becomes raw material for bacteria, so the balance between primary and secondary bile acids is a direct readout of microbial 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propionate","family":"Histidine metabolite","explanation":"Produced when gut bacteria break down the amino acid histidine.","why_it_matters":"A relatively recent finding: higher levels have been reported in people with type 2 diabetes, with laboratory work suggesting it can interfere with insulin signalling. An active research area rather than settled 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intermediate","explanation":"An intermediate product of fermentation, normally consumed by other bacteria almost as fast as it is produced.","why_it_matters":"Because it is usually an intermediate, finding a lot of it suggests the bacteria that normally consume it — converting it onward to butyrate — are not keeping up. Accumulation has been reported in some IBD and infant gut states.","test_pearson_r":0.5994,"intercept":7.680798530578613,"coef":[[89,0.11494617909193039],[101,3.49251389503479],[196,-2.4273688793182373],[235,-1.71595299243927],[279,-2.678912401199341],[382,-1.653543472290039],[557,1.8297466039657593],[601,-7.522078037261963],[613,0.7642290592193604],[614,-0.20963701605796814],[845,-1.2037413120269775],[1257,-11.190048217773438],[1261,-0.2613418698310852]],"quantiles":[0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0497,0.096,0.1364,0.1939,0.28,0.3763,0.5291,0.8993,2.5401,2.6151,2.6779,2.7075,2.7545,2.78,2.807,2.8424,2.8742,2.9171,2.9423,2.9836,3.0184,3.0761,3.1403,3.2088,3.3048,3.5998,3.9795,4.4279,4.6787,4.8836,5.0931,5.3527,5.4898,5.6607,5.9014,6.0704,6.2101,6.3038,6.399,6.5287,6.6405,6.7503,6.8393,6.9299,7.0429,7.1631,7.2621,7.3388,7.447,7.5476,7.6551,7.8203,7.9358,8.0542,8.2218,8.4207,8.6536,8.8991,9.146,9.5571,9.9185,10.1457,10.4581,11.1293,11.6473,11.9353,12.3418,12.5559,12.666,12.7585,12.8252,12.8935,12.9693,13.0233,13.1172,13.1884,13.2621,13.3414,13.4532,13.6056,13.7919,14.1008,14.9191,15.5688,15.8635,16.0451,16.1442,16.286,16.458,16.6844,19.8477]},{"hmdb_id":"HMDB0000682","name":"Indoxyl sulfate","family":"Tryptophan metabolite","explanation":"Formed from bacterial indole, then modified by the liver. Normally cleared by the kidneys.","why_it_matters":"Accumulates when kidney function is impaired, and is one of the best-known 'uraemic toxins' — a case where gut bacterial output and kidney disease 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